Author(s):
Dipannita Naskar, Ujjal Manna, Banhishikha Kar
Email(s):
dipannitanaskar26@gmail.com
DOI:
10.52711/2231-5675.2026.00042 
Address:
Dipannita Naskar1*, Ujjal Manna2, Banhishikha Kar2*
1Department of Pharmaceutics, Gupta College of Technological Sciences, Ashram More, G T Road, Asansol, West Bengal 713301, India.
2Department of Pharmaceutics, Calcutta Institute of Pharmaceutical Technology and AHS, Banitabla, Uluberia, Howrah - 711316, West Bengal, India.
*Corresponding Author
Published In:
Volume - 16,
Issue - 4,
Year - 2026
ABSTRACT:
The simple and rapid spectrophotometric technique has been developed to measure and validate the absorbance of antidiabetic drug linagliptin. This study's objective is to use UV spectroscopy to precisely and accurately estimate the maximum wavelength of the bulk drug and the pH at which the bulk drug exhibits the highest absorbance. The study was aimed to create and verify a new, straight-forward, accurate, and specific UV-Spectrophotometric analysis method of Lornoxicam, by comparing in-between three different types of body fluids, having three different pH, like gastric fluid, physiological fluid and intestinal fluid, and to determine the best site for administration also. UV spectrophotometric analysis was carried out by utilizing a Shimadzu UV-visible spectrophotometer, using three different mediums for the drug linagliptin. The standard solution's spectrum was run from 200 to 400nm range in order to figure out the absorption maximum (?max) of linagliptin, which was discovered at 229 nanometers. According to Beer’s law concentration range of bulk drug and sample is 2-14µg/ml in buffer at pH 1.2, 6.8 and 7.4 respectively. The regression coefficient of each and every equation were found to be above 00.995 which denoted that all equations were following linearity.
Cite this article:
Dipannita Naskar, Ujjal Manna, Banhishikha Kar. UV Spectrophotometric Method Development and Validation for the Determination of Linagliptin into Bulk Drug and Commercial Formulation in different pH Medium. Asian Journal of Pharmaceutical Analysis. 2026; 16(4):274-8. doi: 10.52711/2231-5675.2026.00042
Cite(Electronic):
Dipannita Naskar, Ujjal Manna, Banhishikha Kar. UV Spectrophotometric Method Development and Validation for the Determination of Linagliptin into Bulk Drug and Commercial Formulation in different pH Medium. Asian Journal of Pharmaceutical Analysis. 2026; 16(4):274-8. doi: 10.52711/2231-5675.2026.00042 Available on: https://www.ajpaonline.com/AbstractView.aspx?PID=2026-16-4-4
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